There is no treatment specifically for metabolic syndrome. The condition is treated by managing the underlying conditions and risk factors that are involved.
There are some medications available that your doctor may prescribe for you to help you lose weight. These medications are part of a complete plan that also includes a healthy diet and physical activity.
The most commonly prescribed weight-loss medications are:
—Sibutramine is a prescription medication that is used as an appetite suppressant. This medication, which is available in a pill, is usually only prescribed for you if you are very overweight. Sibutramine is believed to work by increasing the activity of certain chemicals, called norepinephrine and serotonin, in the brain to suppress your appetite.
—Orlistat works by preventing or blocking the fat you eat from being absorbed into your body. The undigested fat is removed in your bowel movements. Orlistat is taken as a pill up to three times a day with each main meal that contains fat. It is important to try to eat a low-calorie, low-fat diet while taking this medication.
—Phendimetrazine is a prescription medication commonly used as an appetite suppressant. This medication comes as a pill. Phendimetrazine is believed to work to increase the activity of certain chemicals in your brain, serotonin, norepinephrine, epinephrine, and dopamine which suppress your appetite.
—Phentermine is a prescription medication commonly used as an appetite suppressant. This medication comes as either a pill or a capsule. Phentermine directly stimulates the satiety center in your brain so that you don’t feel hungry.
—Diethylpropion is a prescription medication commonly used as an appetite suppressant. This medication comes as a pill. Diethylpropion is believed to work by changing the nerve impulses going to the appetite control center in your brain and suppresses hunger.
Your doctor will test your cholesterol levels, and you can work together to choose the medications that will work best for you. The purpose of using cholesterol medications is to reduce your LDL cholesterol (the “bad” cholesterol) and increase your HDL (the “good” cholesterol). The medications also work to decrease the level of triglycerides (a kind of fat found in your blood and considered another type of “bad cholesterol”) in your blood.
Exetimibe-Ezetimibe (<![CDATA]>Zetia<![CDATA]>)—Used alone or in combination with statins, this new class of drugs lowers cholesterol by blocking the absorption for the intestines. As in other cholesterol-lowering drugs, its use should be in conjunction with diet and exercise.
Statins—Statins are used to reduce the amount of cholesterol in your blood. The medications, available in pill form, are usually taken right before bed. They block an enzyme (HMG-CoA reductase) that the body needs to produce cholesterol, so less cholesterol is produced and less cholesterol is in the blood. Medications include:
Fibric Acid Derivatives—Fibric acid derivatives are also known as fibrates. They work by reducing the production of triglycerides and increasing HDL cholesterol (the “good” cholesterol). Medications include:
<![CDATA]>Niacin<![CDATA]>—Niacin has been found to lower triglyceride levels and LDL levels and raise HDL levels. The use of niacin to treat cholesterol requires careful monitoring because the medication may increase production of glucose (sugar in your blood). Medications include:
Niaspan (niacin extended-release tablets): available by prescription
Niacor or Nicolar (niacin): available over-the-counter
Omega-3-Fish oil has been found to lower triglyceride by 20 to 50%. In some individuals, it may raise LDL cholesterol and also raise HDL cholesterol slightly. Medications include:
Omega-3 fatty acid available over-the-counter
Omacor, prescription omega-3 acid ethylesters
Medications to Lower Blood Pressure
The major types of medications used to control high blood pressure include:
Angiotensin-converting Enzyme (ACE) Inhibitors—ACE inhibitors help relax and widen the blood vessels, making it easier and requiring less force (pressure) to let the blood flow through the blood vessels. This lowers your blood pressure. Medications include:
Angiotensin II Receptor Blockers—These medications block the action of angiotensin II, a substance that causes the blood vessels in your body to constrict (or tighten), making it harder for blood to pump and flow through the vessels. Medications include:
Doctors use medications to decrease insulin resistance in people with
. These medications may also help improve insulin metabolism in people with metabolic syndrome.
Thiazolidinediones—These drugs help your body to better use insulin, a protein hormone that lets your body metabolize and use glucose. It also reduces glucose production in the liver. Medications include:
—These medications lower blood glucose levels by decreasing the amount of glucose produced by the liver. Medications include:
<![CDATA]>Metformin<![CDATA]> (Glucophage, Glucophage XR)—Studies have found that metformin can reduce metabolic syndrome in people with high blood sugar.
Sulfonylureas—These medications make the pancreas, a gland that plays a role in digestion, release more insulin. The only medication currently available is <![CDATA]>chlorpropamide<![CDATA]> (Diabinese).
Meglitinides—These medications stimulate cells that make insulin to release insulin and are taken before each meal. Medications include:
Dipeptidyl peptidase-4 (DPP-4) Inhibitors—These medications lower blood glucose by slowing down the inactivation of glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This allows better glucose control. Medications include:
Proinflammatory and Prothrombotic State—The American Heart Association recommendation is that those patients with a 10-year risk for cardiovascular diase of 10% or greater should be treated with low-dose <![CDATA]>aspirin<![CDATA]>.
Berger JS, Roncaglioni MC, Avanzini F et al: Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials. JAMA. 2006;295:306-13.
Beta blockers for heart problems. FamilyDoctor.org, American Academy of Family Physicians website. Available at:
. Accessed August 2, 2005.
Brazg R, Xu L, Dalla Man C et al: Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab. 2007;9:186-93.
Orchar TJ, Temprosa M, Goldberg R, et al. The effect of diet and exercise or metformin on the metabolic syndrome: The diabetes prevention program randomized trial.
Annals of Internal Medicine.
Please be aware that this information is provided to supplement the care
provided by your physician. It is neither intended nor implied to be a
substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER
IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the
advice of your physician or other qualified health provider prior to
starting any new treatment or with any questions you may have regarding a