Definition

X-linked adrenoleukodystrophy (ALD) is a rare inherited genetic disorder. There have been 34 types of ALD described. X-linked ALD is the most common category. ALD results in degeneration of:

• Myelin sheath—fatty insulation covering on nerve fibers in the brain
• Adrenal gland and surrounding adrenal cortex—produces vital hormones

Myelin Sheath Around Nerve Fiber

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There are six types of X-linked ALD:

• Childhood cerebral ALD
• Adolescent ALD
• Adrenomyeloneuropathy
• Adult cerebral ALD
• Adrenal insufficiency-only
• Symptomatic heterozygotes

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