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Pap or HPV Test to Find Cervical Cancer: Which Comes Out on Top?

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HPV or Pap Test to Find Cervical Cancer: Which Comes Out on Top? MonkeyBusiness Images/PhotoSpin

More than 12,000 U.S. women were diagnosed with cervical cancer and roughly 4,000 died from the disease in 2011, according to Inquisitr.com.

When it comes to detecting cervical cancer, the Pap test has been the gold standard for decades. But as human papillomavirus virus (HPV) continues to emerge as a leading contributor to cervical cancer, HPV screening is rivaling the Pap.

Both the Society of Gynecologic Oncology and the American Society for Coloposcopy and Cervical Pathology recently suggested that the HPV test performs better than the Pap at detecting cancer, Indianapolis Star (IndyStar) reported.

They proposed replacing the Pap smear with the HPV test as the first screen for most women.

With a Pap smear, cells are scraped from the surface of the cervix. Doctors look for abnormal cells that could turn in to cervical cancer.

The HPV test detects the presence of two strains of HPV, which are responsible for about 70 percent of cervical cancer cases.

"Pap smears are notoriously unreliable when it comes to detecting cancer. As many as one in 10 abnormal tests are read as normal," Dr. Kelly Kasper, associate clinical professor of obstetrics and gynecology at Indiana University School of Medicine told IndyStar.

A recent study, published in the Journal of the National Cancer Institute, said that women with a negative HPV test had half the risk of developing cancer over three years as women who had a negative Pap test. Their rates were similar to those of women who were negative on both tests.

Since most cervical cancer cases are caused by an HPV infection, women who show no signs of HPV are at a very low risk of developing the cancer — even lower than women who have a negative Pap test.

"The thing that is unique about the test; it's either positive or negative," Dr. Warner Huh, a professor of gynecologic oncology at the University of Alabama, who proposed that HPV testing be considered as a solo alternative to Pap testing told IndyStar.

"When that test is negative, there is an extraordinarily high chance she will not get cancer within three years. You can't make the same claim with Pap testing."

In April, the U.S. Food and Drug Administration (FDA) approved an HPV DNA test as a primary screening tool for cervical cancer for women 25 and older. This test can determine whether a woman is infected with HPV, and whether the type is one of the two cancer-causing strains.

Along with the approval, the FDA offered guidelines on how the test should be used. It was advised that women who test positive for HPV 16 or HPV 18 (the two cancer-causing strains) should have a colposcopy, or a procedure that magnifies the cervix to get a better look at abnormal cells and take biopsies if needed.

If women test positive for other strains of HPV, they get a Pap test as a followup to determine the state of their cells.

Sources:

"New HPV Test May Help Detect Cervical Cancer Sooner." The Inquisitr News. Web. 13 Jan. 2015.
http://www.inquisitr.com/1740261/new-hpv-test-may-help-detect-cervical-cancer-sooner

Rudavsky, Shari. "Will HPV Test Replace Pap in Detecting Cervical Cancer?" Will HPV Test Replace Pap in Detecting Cervical Cancer? Web. 13 Jan. 2015.
http://www.indystar.com/story/life/diet-fitness/2015/01/11/will-hpv-test-replace-pap-detecting-cervical-cancer/21578457

Sifferlin, Alexandra. "HPV Test vs. The Pap Smear: Which Detects Cancer Better?" Time. Time. Web. 13 Jan. 2015.
http://time.com/3025178/hpv-test-vs-the-pap-smear-which-detects-cancer-better

Reviewed January 15, 2015
by Michele Blacksberg RN
Edited by Jody Smith

Add a Comment1 Comments

EmpowHER Guest
Anonymous

The sixth paragraph in this article appears to indicate that the HPV test only detects the presence of 2 strains responsible for 70% of cervical cancers. While this statement is indirectly referring to HPV 16 and HPV 18 genotypes, it should clarify that 12 other high-risk HPV genotypes are also detected with this HPV test.

January 20, 2015 - 3:11pm
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