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Basic cleaning is totally doable, but deeper sanitation usually requires pro equipment. That said, I found this guide incredibly helpful for https://comfortclean.com/how-to-clean-air-ducts-in-house-step-by-step-guide-for-homeowners/ how to clean ducts in a house. It walks you through which parts you can safely access, how to remove and clean vent covers, and even how to handle basic mold concerns. I tried it last fall and was able to clean most of the main vents. Just be careful not to damage insulation or wiring inside the ducts. It’s a great way to extend time between pro cleanings and keep your indoor air healthier.