How I get rid of a large callus on my hand?

A callus is just a rough, thick patch of skin and it will go away by itself over time. Think of a guitar player's fingers -- when they practice consistently, they build up strong calluses, but if they lay off for too long, the calluses go soft and the building-up process has to begin again.

We get calluses because of repeated use and pressure on an area of skin. We get them most often on our hands and on our feet (especially if you're a barefoot girl in the summer!)

You can help a callus go away faster by soaking it in warm, soapy water for 10 minutes (an excuse for a relaxing bath!), then rubbing it with a pumice stone.

Here's a page on how to remove that callus:

http://www.associatedcontent.com/article/67270/how_to_remove_a_callus.html

So many medicines now come in your choice of kid-proof or regular-type bottles. Too bad yours doesn't. Perhaps it would be worth it to find a clean jar (like a spice jar with the label removed) or plastic container that you could use for that medicine, label it with a magic marker and use that instead of the bottle it comes in? Even if you just put a week's worth of medicine in it at a time, you'd only have to get in the original bottle once a week. That might be enough to get that callus to go away.