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Please speak with your gynecologist. Report specifically how estradiol is making you feel sick.
Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.
Estradiol is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.
Your doctor can work with you to find an alternative therapy. Dr. Andrew Weil offers this article.
"Alternatives to Estrogen?"
Losing weight gets harder as our metabolic rate slows down. Try to burn more calories than you consume. Exercise regularly. Cut back on portion size. Look at your caloric intake. Eat more fruits and vegetables. Drink more water and less sugary drinks.