Please cite references for data showing statins decrease mortality in women. In addition, could you provide the NNT (number needed to treat) for any statin use in women? or men over the age of 65 who take statins for primary prevention? Or anyone who takes statins for primary prevention? How about the Number needed to Harm? Could you cite any of those statistics? You fail to mention the most recent studies indicating statin use is associated with development of type II Diabetes. This interview also fails to mention the very real evidence of severe myopathy (via muscle biopsy) which does occur WITHOUT increases in any measureable enzyme levels. All those muscle aches complaints in individuals who do not have abnormal enzyme levels can be (not often measured because of cost) associated with real changes in muscle structures.
Perhaps you could comb through the FDA ADR reports on statins before you advise about statins use, especially in a population for whom there is no evidence that they impact mortality and ARE associated with considerable adverse effects. In addition, you do not mention the genetic studies noting a relatively common (26 to 34%) prevalence of mutations in a gene, SLCO1B1*15 and (less common, 5-6%) SLCO1B1*5 that encodes the gene responsible for the transport protein that moves statins into the liver for Phase II detoxification , resulting in greatly increased plasma statin levels, due to inability to detoxify statins correctly. I feel you have provided less than accurate information, glossing over the ADRs which are real and can be, if not lethal, at least debilitating.
In addition, could you provide any COI's (conflicts of interest)? In the spirit of transparency. Mine is that YES, I feel I have suffered irrepairable damage from statins, the onset of a neurodegenerative disease. "Miracle drug"? Certainly not for me and the "primary prevention" for which I received Lipitor for 4 yrs.
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Please cite references for data showing statins decrease mortality in women. In addition, could you provide the NNT (number needed to treat) for any statin use in women? or men over the age of 65 who take statins for primary prevention? Or anyone who takes statins for primary prevention? How about the Number needed to Harm? Could you cite any of those statistics? You fail to mention the most recent studies indicating statin use is associated with development of type II Diabetes. This interview also fails to mention the very real evidence of severe myopathy (via muscle biopsy) which does occur WITHOUT increases in any measureable enzyme levels. All those muscle aches complaints in individuals who do not have abnormal enzyme levels can be (not often measured because of cost) associated with real changes in muscle structures.
December 3, 2011 - 8:08amPerhaps you could comb through the FDA ADR reports on statins before you advise about statins use, especially in a population for whom there is no evidence that they impact mortality and ARE associated with considerable adverse effects. In addition, you do not mention the genetic studies noting a relatively common (26 to 34%) prevalence of mutations in a gene, SLCO1B1*15 and (less common, 5-6%) SLCO1B1*5 that encodes the gene responsible for the transport protein that moves statins into the liver for Phase II detoxification , resulting in greatly increased plasma statin levels, due to inability to detoxify statins correctly. I feel you have provided less than accurate information, glossing over the ADRs which are real and can be, if not lethal, at least debilitating.
In addition, could you provide any COI's (conflicts of interest)? In the spirit of transparency. Mine is that YES, I feel I have suffered irrepairable damage from statins, the onset of a neurodegenerative disease. "Miracle drug"? Certainly not for me and the "primary prevention" for which I received Lipitor for 4 yrs.
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