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Hi, your wife has depression, antidepressants may help but usually only mask her feelings deep inside her inner self. She needs to find that inner self again, she needs to love herself again before she can love you.
The best thing to do would be to discuss this rationally and calmly with your wife, say how much you love her but what she says hurt you. You don't want to divorce but can't live like this either. Start counselling as individuals and then together, try meditation *You-tube "Mind Silence" works exceptionally well for me. You married her for a reason. Never "react" to her just "respond" to her if she is argumentative. If she says something that hurts you go for a a walk or do something else, so she knows her behaviour is not acceptable. When she has calmed down, then discuss with her, don't let it go and walk on eggshells till it blows up again. Maybe she has autism or aspergers or depression or both, either way she is unhappy, she will not be happy with you until she is happy with herself. Just love her no matter what, little things, you can and will break through.