Thanks for helping spread the word about tamoxifen drug interactions. As a prodrug requiring CYP2D6 conversion to be effective, tamoxifen should not be taken with any potent CYP2D6 inhibitor as some SSRIs are. Here is a list of common CYP2D6 inhibitors from http://www.healthanddna.com/Druglist.pdf:
You may be interested in Tamoxitest, a combined Tamoxifen resistance test and software that scans for drug-drug, drug-herbal, and drug-gene interactions that can reduce tamoxifen efficacy. More information is at www.Tamoxitest.com
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Hi Dr. Dae:
Thanks for helping spread the word about tamoxifen drug interactions. As a prodrug requiring CYP2D6 conversion to be effective, tamoxifen should not be taken with any potent CYP2D6 inhibitor as some SSRIs are. Here is a list of common CYP2D6 inhibitors from http://www.healthanddna.com/Druglist.pdf:
amiodarone
{amitriptyline}
bupropion
celecoxib
chlorpheniramine
chlorpromazine
cimetidine
cinacalcet
{citalopram}
chlorpheniramine
clomipramine
{desipramine}
diphenhydramine
doxepin
duloxetine
{fluvoxamine}
fluoxetine
goldenseal
halofantrine
haloperidol
{hydroxyzine}
imipramine
methadone
metoclopramide
moclobemide
paroxetine
pimozide
propafenone
quinidine/quinine
ritonavir
{sertraline}
terbinafine
thioridazine
ticlopidine
You may be interested in Tamoxitest, a combined Tamoxifen resistance test and software that scans for drug-drug, drug-herbal, and drug-gene interactions that can reduce tamoxifen efficacy. More information is at www.Tamoxitest.com
September 9, 2009 - 3:09pmThis Comment
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