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When Are Biologic Drugs an Option for Crohn’s Disease?

By EmpowHER
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doctor explaining biologics to patient

Biologic drugs

Crohn’s disease causes inflammation, swelling, and irritation in the lining of the digestive tract.

If you have tried other treatments for Crohn’s disease and they haven’t worked, you might consider biologic drugs. Biologics are prescription drugs that help reduce harmful inflammation from Crohn’s disease.

Keep reading to find out if biologics are right for you.

What are biologic therapies?

Biologics are genetically engineered medicines that target certain molecules in the body involved in causing inflammation.

Doctors often prescribe biologics to those with refractory Crohn’s disease or moderate to severe symptoms that aren’t going away with other medications. Before biologics, there were few nonsurgical treatment options for people with refractory disease.

Biologic therapies work to quickly bring on remission. During a period of remission, inflammation and intestinal symptoms go away. Biologics may also be used on a long-term basis to help maintain periods of remission.

Types of biologics

The type of biologic your doctor suggests will depend on the severity of your symptoms and the location of disease.

Everyone is different. A certain biological drug may work better for some than others. You may have to try a few medications before finding what works for you.

Biological therapies for Crohn’s disease fall into one of two categories: anti-tumor necrosis factor (anti-TNF) therapies and anti-integrin antibodies.

Anti-TNF therapies target a protein that’s involved in inflammation. For Crohn’s disease, anti-TNF therapies work by blocking inflammation caused by this protein in the intestines. Anti-integrins block certain immune system cells that cause inflammation.

Biologics are typically given either subcutaneously (with a needle through the skin) or intravenously (through an IV tube). They may be given every two to eight weeks, depending on the medication. You’ll have to go to a hospital or clinic for most of these treatments.

The FDA has approved several biological drugs to treat Crohn’s disease.

Anti-TNF medications include:

Anti-integrin antibodies include:

]]> Step-up versus top-down treatment

Biologic therapies can be a powerful tool in the treatment and management of Crohn’s disease. There are two different approaches to biologic therapy:

  • Step-up therapy is the conventional approach. It means that you and your doctor try several other treatments before starting a biologic.
  • Top-down therapy means that biologic medications are started much earlier in the treatment process.

The medical community is split on which approach works best. There may not be one right answer. Different approaches may work better for different people depending on the severity and location of the disease.

Side effects

Biologics tend to have fewer side effects that are less harsh than other Crohn’s disease medications, such as corticosteroids, which suppress the entire immune system.

Still there are certain side effects you should know about before taking a biologic medicine.

Some common side effects of biologics include:

  • redness, itching, bruising, pain, or swelling around the injection site
  • headache
  • fever or chills
  • difficulty breathing
  • low blood pressure
  • hives or rash
  • stomach pain
  • back pain
  • nausea
  • cough or sore throat

Special considerations

Biologics may not be safe for everyone. Talk to your doctor if you have tuberculosis (TB), are prone to infections, or have a heart condition.


Anti-TNF drugs can increase the risk of reactivating a tuberculosis infection in people who have been exposed. TB]]> is a serious, infectious lung disease.

Your doctor should test you for TB before starting therapy with an anti-TNF drug. A TB infection can be dormant in the body. Some people who have been exposed to the disease might not know it. If you’ve had prior exposure to TB, your doctor may recommend TB treatment before taking an anti-TNF.


Biologics can lower the body’s ability to fight other infections. If you’re prone to infections, your doctor may suggest a different type of therapy.

Heart conditions

Biologic drugs may be risky for people with certain heart conditions, such as heart failure. Heart failure is when the heart can’t pump enough blood to meet the body’s needs.

Tell your doctor as soon as possible if you experience shortness of breath or swelling of the feet while taking a biologic for Crohn’s disease. These may be signs of heart failure.

Other issues

Biologic therapies have occasionally been linked with serious health problems. In people taking anti-TNF drugs, the following health problems are rarely reported:

  • certain blood disorders (bruising, bleeding)
  • neurological problems (including, numbness, weakness, tingling, or visual disturbances, such as blurred vision, double vision, or partial blindness)
  • lymphoma
  • liver damage
  • severe allergic reactions

Talk with your doctor to determine the best therapy for you and your needs.

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