Everybody knows about midlife crisis, because it is very common. And it is not benign, it may destroy life. Unfortunately mood changes are very often, and the common treatment is antidepressants, sleeping pills or antianxiety medications. The fact that problems start at about age after 40 made one think that it might be related to aging. So what are the plausible explanation of this problem, recognised worldwide? The mid life crisis might be explained by sex hormone production decline, resulting in depression and/or anxiety. Changes in adrenal hormones secretion rate because of stress is another plausible explanation. The solution of mid life crisis might be hormonal status evaluation and correction if necessary along with stress management. Sergey Kalitenko, MD www.doctorkalitenko.com