Tina's post about depression being exacerbated by certain medications got me wondering about the so-called natural anti-depressants like Sam-e and St. John's Wart.

Many doctors advice depressed patients to take them alongside prescription medications for depression, particularly when the prescriptions are not working well.

Research into these herbal anti-depressives is usually positive, particularly St. John's Wart.

Has anyone tried these herbal supplements? What was the outcome? Did you have a positive or negative experience or did you notice any difference at all?