WEDNESDAY, June 4 (HealthDay News) -- A new molecular signaling pathway in fat cells that suppresses harmful inflammation has been identified by Harvard School of Public Health researchers. The pathway prevents the fat cells -- called adipocytes -- from over-reacting to inflammation-causing stimulants such as fatty acids in the diet.
However, the researchers also found that obesity-related cellular stress can override the protective function and turn the pathway into a trigger of chronic inflammation, leading to increased risk of insulin resistance, diabetes and other metabolic disorders.